Archives of Clinical and Experimental Ophthalmology

Original Research Open Access

Ocular surface disease management in cataract surgery

Alessandro Mularoni , Antonio Di Zazzo , Daniele Gaudenzi , Francesco Cutrupi , Francesco Gaudenzi , Giovanna Linda Possati

According to the literature, 80% of patients undergoing cataract surgery suffer from ocular surface disease (OSD). Along with postoperative refractive surprise, the onset of OSD is the main cause of dissatisfaction in cataract surgery patients, accounting for 35% of cases. These patients are characterized by persistent dysregulation of ocular surface para-inflammation, leading to chronic low- grade inflammation with significant consequences on daily activities and work productivity. This study aims to investigate the effects of topical desonide sodium phosphate 0.025% eye drops on the signs and symptoms of OSD in patients undergoing cataract surgery.

Commentary Open Access

Comment on “Use of refractive aids among adults in a general population”

Ivan Nisted , Bodil Hammer Bech , Toke Bek

This commentary is a further discussion of results from the FORSYN study recently published in Scientific Reports [1]. In the FORSYN study 10,350 people selected by Statistics Denmark to represent the adult Danish population with respect to age, sex, and socio-economical parameters were invited for a non-cycloplegic examination at the Department of Ophthalmology, Aarhus University Hospital.

Commentary Open Access

Considerations regarding the visual and social limitations of children with congenital Zika syndrome 

Marcia Beatriz Tartarella, MD, PhD , João Borges Fortes Filho, MD, PhD , Islane Maria de Castro Verçosa, MD

Congenital Zika syndrome (CZS) results from maternal exposure to the Zika virus during pregnancy. A large number of newborns were affected during the Zika virus outbreak occurred insome Northeast regions of Brazil during the years 2015 and 2016 .

Commentary Open Access

Commentary on analysis of contrastsensitivity in patients implanted with AcunexVario and LuxSmart extended depth of focus (E-DOF) intraocular lenses (IOLs)

Boryana Irinkova

The significance of contrast sensitivity (CS) in impacting real visual ability cannot be emphasized enough. In recent years, cataract surgeons and ophthalmologists globally have been focusing more on it. Visual acuity is no longer the sole measure of vision quality, especially in low-light conditions.

Commentary Open Access

Long-term success in phacoemulsification surgery: what can we learn?

Orezime Mayor Atima , Emeka John Dingwoke

Phacoemulsification has become the gold standard in cataract surgery due to its effectiveness and rapid visual recovery. Understanding the long-term factors influencing surgical success is critical, particularly in resource-limited settings.

Commentary Open Access

Non-human primate models and multimodal technologies synergistically drive translational breakthroughs in gene therapy for optic nerve diseases

Jian Wu

This commentary systematically examines the pivotal role of non-human primate (NHP) models in advancing gene therapy for optic nerve diseases, alongside the ethical and practical challenges they face. It highlights how synergistic innovations in artificial intelligence (AI), organoid technology, CRISPR-based gene editing, and novel delivery systems are reshaping translational paradigms.

Review Article Open Access

Complement C5 inhibition in acute AQP4-IgG NMOSD attacks: A review of the rationale and clinical evidence

José M. Valdés , Juan P. Mansilla , Tamara Santibañez , Lorna Galleguillos

Neuromyelitis optica spectrum disorder (NMOSD) with aquaporin-4 immunoglobulin G positivity (AQP4-IgG) is a severe autoimmune disease of the central nervous system (CNS) characterized by inflammatory attacks targeting the optic nerves and spinal cord. Pathologically, these attacks are driven by the binding of pathogenic AQP4-IgG to astrocytes, which triggers a potent, complement-dependent cytotoxicity.