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Journal of Cancer Biology
ISSN: 2692-7896
Latest Articles
Thyroid cancer-tumor immune microenvironment (TIME) spatial transcriptomics reveals novel players
Shafiya Imtiaz Rafiqi, DVM, PhD , Juan Carlos Jaume, MD
Thyroid cancer (TC) encompasses several pathological types, notably papillary thyroid cancer (PTC), follicular thyroid cancer (FTC), medullary thyroid cancer (MTC), and anaplastic thyroid carcinoma (ATC). While PTC accounts for the most common type, ATC, despite representing only 1–2% of all TC cases, is recognized as the most lethal and treatment-resistant endocrine malignancy. Despite sharing a common cellular origin, these two subtypes differ markedly in their clinical trajectories, response to therapy, and immune profiles.
J Cancer Biol, 2025, Volume 6, Issue 2, p76-81 | DOI: 10.46439/cancerbiology.6.077
Bridging cancer and neurodegenerative disease: Drug repositioning through cheminformatic, bioinformatic, and systems biomedicine approaches
Hui-Heng Lin , Koken Hirose , Yifan Zhu
Neurodegenerative diseases, such as the Alzheimer and the Parkinson's, currently lack effective pharmacotherapies. They are posing a significant global health threat, and it is urgent to discover and develop effective pharmacotherapies for patients. However, due to pathogenic mechanisms are poorly understood, the interventional drug clinical trials for neurodegenerative diseases have high failure rates.
J Cancer Biol, 2025, Volume 6, Issue 2, p82-90 | DOI: 10.46439/cancerbiology.6.078
Unleashing Wnts: Wnt ligands fuel cancer spread
Kailey P. Caroland , Jonathan B. Trapani , Ethan Lee , Vivian L. Weiss
Wnt signaling has long been implicated in cancer development, but recent studies have revealed new insights into how Wnt ligands themselves drive metastasis. Currently, research identifies Wnt1, Wnt2, Wnt2b, Wnt3, Wnt3a, Wnt4, Wnt5a, Wnt5b, Wnt6, Wnt8a, Wnt9b, Wnt10a, Wnt10b, and Wnt16 as pro-metastatic Wnt ligands, while Wnt7a, Wnt7b, Wnt8b, Wnt9a, and Wnt11 exhibit conflicting pro- and anti-metastatic roles.
J Cancer Biol, 2025, Volume 6, Issue 2, p91-107 | DOI: 10.46439/cancerbiology.6.079