Journal of Clinical and Experimental Gastroenterology

Original Research Open Access

The effect of tirofiban hydrochloride on colon anastomosis healing in hypoperfusion ischemia induced in rats

Guvenc Diner , Mustafa Ugur , Muhyittin Temiz , Ahmet Aslan

Objective: Anastomotic insufficiency in colorectal surgery can lead to serious complications and high morbidity and mortality rates. This study aimed to evaluate the effect of tirofiban hydrochloride, an antiplatelet agent, on ischemic colon anastomosis healing.A total of 21 male Wistar albino rats were randomly divided into three groups: Group A (Sham), Group B (Ischemia-Control), and Group C (Ischemia-Tirofiban).

J Clin Exp Gastroenterol, 2026, Volume 5, Issue 1, p1-6 | DOI: 10.46439/gastro.5.028

Original Research Open Access

Vedolizumab in Indian patients with inflammatory bowel disease: final results from a prospective, multicenter, open-label, phase 4 study

Mayank Kabrawala , Rupa Banerjee , Vineet Ahuja , Anumula Kavitha , Vaishali Bharadwaj , Ashok Dalal , B Ramesh Kumar , Shrikant Mukewar , Ajit Sood , VG Mohan Prasad , Sandeep Arora , Gaurav Bahuguna , Avi Sharma

Background: There is limited data on the effectiveness and safety of vedolizumab for Indian patients, making this study the first focused evaluation of its use in this population.This prospective, multicenter, open-label phase IV study enrolled patients aged 18–65 with moderate to severe ulcerative colitis (UC) or Crohn's disease (CD), who received vedolizumab 300 mg IV at weeks 0, 2, and 6 (induction) and at weeks 14, 22, 30, 38, and 46 (maintenance). 

J Clin Exp Gastroenterol, 2026, Volume 5, Issue 1, p7-14 | DOI: 10.46439/gastro.5.029