Abstract
A series of studies suggested that hypertension is significantly associated with the risk of gallstone disease (GSD). However, due to differences in study design, population stratification, sample size, and diagnostic criteria for GSD, the results of each study are inconsistent, limiting the strength and application of these pieces of evidence. We previously conducted a cross-sectional study incorporating over 300,000 population, and the results showed hypertension was significantly associated with the risk of GSD. However, it was a single-center study, and the external generalization of research results is limited to a certain extent. Thus, we conducted another multi-center study and a systematic review and meta-analysis to verify further the relationship between hypertension and the risk of GSD.
Keywords
Gallstone diseases, Hypertension, Multi-center study, Systematic review and meta-analysis