Cell Signaling

Commentary Open Access

Unlocking the significance of CD226 in cancer

Weili Sun

CD226 is a transmembrane glycoprotein with a well-defined structural organization, which is primarily expressed on natural killer (NK) cells, cytotoxic T cells, and some subsets of B cells [1,2]. Its primary structure consists of an extracellular domain, a transmembrane domain, and a cytoplasmic tail [1]. Each of these domains contributes to the protein's overall function.

Research Article Open Access

Methylphenidate (Ritalin) affects serotoninsignaling differently in young compared to adults. Concomitant behavioral and neuronal recording from dorsal raphe in freely behaving rats

Elizondo GM, Raymond A, Perez-Vasquez C, Dafny N

Attention deficit hyperactivity disorder (ADHD) is a complex behavioral disorder characterized by hyperactivity, increased impulsivity, and inattention [1-3]. Methylphenidate (MPD) is the most
commonly prescribed psychostimulant for management and treatment of ADHD [3-7].

Commentary Open Access

Do arrestin oligomers have specific functions?

Vsevolod V. Gurevich

Arrestins were discovered as key players in the conserved two-step homologous desensitization of G protein-coupled receptors (GPCRs): they specifically bind active phosphorylated GPCRs, precluding their coupling to cognate G proteins, thereby stopping (“arresting”) G protein-mediated receptor signaling [1]. 

Commentary Open Access

Accelerating metal nanocluster synthesis: A high-throughput approach with machine learning assistance

Li Tang, Shuxin Wang

Metal nanoclusters, consisting of a few to a few hundreds of metal atoms, have been of great scientific interest due to their potential applications in areas like bio-labeling and catalysis [1-9].

Commentary Open Access

Sample multiplexing in CyTOF: Path to optimize single-cell proteomic profiling

Muharrem Muftuoglu, Michael Andreeff

In biomedical research, achieving single-cell resolution in investigation of cellular systems is of paramount importance. Ongoing research efforts to explore and decode the heterogeneity in cellular phenotype, functionality, genomics, epigenetics, and transcriptomics in biological systems have propelled significant technological advancements through innovative breakthroughs [1-3].

Commentary Open Access

Potential biomarkers for MCL1 inhibitor sensitivity

Lei Duan, Carl G. Maki

Myeloid cell leukemia-1 (MCL1) is an anti-apoptotic member of the B-cell lymphoma 2 (BCL- 2) family and plays a key role in cancer cell survival and resistance to therapy [1,2]. MCL1 is often
overexpressed in cancers such as leukemia, lymphoma, and solid tumors, allowing cancer cells to evade apoptosis and resist conventional treatments.